Endocrine Abstracts

After a period in research and academia, it is difficult to envisage an alternative career. However, there are a surprising number of opportunities available although it does require some determination to discover them. One of these is to join a medical education, or communications agency. These companies work mainly with pharmaceutical companies and generally cover a range of therapeutic areas. There are many such agencies ranging from those with a small number of employees t...

Variation in glucocorticoid (Gc) sensitivity underlies metabolic disease, and affects therapeutic response in inflammation. Using an in-vitro screening approach we identify two new mechanisms capable of regulating Gc sensitivity.The first involves interferon induced factor 16 (IFI16). IFI16 potentiated both transactivation, and Gc repression of NFκB. IFI16 did not affect glucocorticoid receptor (GR) expression, ligand dependent repression of GR expr...